Scientific Literature

 

Phospholipase A2 as a trigger for targeted drug delivery

Enzymatic Release of Anti-tumor Ether Lipids by Specific Phospholipase A2 Action of Novel Liposome-forming prodrugs.
Author: T. L. Andresen, J. Davidsen, M. begtrup, O. G. Mouritsen and K. Jørgensen
Triggered Activation and Release of Liposomal Prodrugs and Drugs in Cancer Tissue by Secretory Phospholipase A2.
Author: T. L. Andresen, S. S. Jensen, T. Kaasgaard and K. Jørgensen, 2005
Synthesis and membrane behavior of a new class of unnatural phospholipid analogs useful as phospholipase A2 degradable liposomal drug carriers.
Author: T. L. Andresen and K. Jørgensen, 2005
Advanced strategies in liposomal cancer therapy: Problems and prospects of active and tumor specific drug release.
Author: T. L. Andresen, S. S. Jensen and K. Jørgensen, 2005
Synthesis and Biological Activity of Anticancer Ether Lipids that are Specifically Released by Phospholipase A2 in Tumor Tissue.
Author: T. L. Andresen, S. S. Jensen, R. Madsen and K. Jørgensen, 2005
Active and Tumour Specific Drug Release Using Targeted Liposomal Drug Carriers.
Author: T.L. Andresen, S. S. Jensen and K. Jørgensen, 2004
Secretory phospholipase A2 as a tumor-specific trigger for targeted delivery of a novel class of liposomal prodrug anticancer etherlipids.
Author: S. S. Jensen, T. L. Andresen, J. Davidsen, P. Høyrup, S. D. Shnyder, M. C. Bibby, J. H. Gill and K. Jørgensen, 2004
Secreted Phospholipase A2 as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue.
Author: J. Davidsen, K. Jørgensen, T. L. Andresen and O. G. Mouritsen, 2003
Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes.
Author: J. Davidsen, O. G. Mouritsen and K. Jørgensen, 2002
Biophysical Mechanisms of phospholipase A2 activation and their use in liposome-based drug delivery.
Author: K. Jørgensen, J. Davidsen and O. G. Mouritsen, 2002

Phospholipase A2 in Cancer tissue

Increased Expression and Activity of Group IIA and X Secretory Phospholipase A2 in Peritumoral versus Central Colon Carcinoma Tissue.
Author: L. Tribler et al, 2007
Expression of Group IIA Secretory Phospholipase A2 Is Elevated in Prostatic Intraepithelial Neoplasia and Adenocarcinoma.
Author: J. Pathl. J. Jiang et al, 2002
Expression of Group IIa Secretory Phospholipase A2 Increases with Prostate Tumor Grade.
Author: J. R. Graff et al, 2001
Immunohistochemical localization of group II phospholipase A2 in the tumours and mucosa of the colon and rectum.
Author: I Edhemovic, M. Snoj, A. Kljun and R. Golouh, 2001
Group II and IV phospholipase A2 are produced in human pancreatic cancer cells and influence prognosis.
Author: M. Kashiwagi et al, 1999
Overexpression of the Nonpancreatic Secretory Group II PLA2 Messenger RNA and Protein in Colorectal Adenomas from Familial Adenomatous Polyposis Patients.
Author: P. B. Kennedy et al, 1998
Group II phospholipase A2 is increased in peritoneal and pleural effusions in patients with various types of cancer.
Author: T. Abe et al, 1997

Phospholipase A2 in general

Molecular Basis of Phospholipase A2 Activity toward Phospholipids with sn-1 Substitutions.
Author: J. L. Linderoth et al, 2008
Synthesis of sn-1 functionalized phospholipids as substrates for secretory phospholipase A2.
Author: Linderoth et al, 2007
Activation of Interfacial Enzymes at Membrane Surfaces.
Author: O. G. Mouritsen, T. L. Andresen et al, 2006
Domain-Induced Activation of Human Phospholipase A2 Type IIA: Local versus Global Lipid Composition.
Author: J. C. Leidy, L. Linderoth, T. L. Andresen, O. G. Mouritsen, K. Jørgensen and G. H. Peters, 2006
Phospholipase A2.
Author: M. Murakami and I. Kudo, 2002
Phospholipase A2 – an Enzyme that is Sensitive to he Physics of its Substrate.
Author: P. Høyrup, K. Jørgensen and O. G. Mouritsen, 2002
Interfacial Enzymology: The Secreted Phospholipase A2-Paradigm.
Author: O. G. Berg, M. H. Gelb, M.-D. Tsai and M. K. Jain, 2001
In Situ Atomic Force Microscope Imaging of Supported Lipid Bilayers.
Author: T. Kaasgaard, C. Leidy, J. H. Ipsen, O. G. Mouritsen and K. Jørgensen, 2001
The expanding superfamily of phospholipase A2 enzymes: Classification and characterization.
Author: D. A. Six and E. A. Dennis, 2000